Drug design targeting the main protease, the Achilles' heel of coronaviruses : SARS-CoV: A scénario of modern drug design
Identifieur interne : 004460 ( Main/Exploration ); précédent : 004459; suivant : 004461Drug design targeting the main protease, the Achilles' heel of coronaviruses : SARS-CoV: A scénario of modern drug design
Auteurs : HAITAO YANG [République populaire de Chine] ; Mark Bartlam ; ZIHE RAOSource :
- Current pharmaceutical design [ 1381-6128 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médicament.
English descriptors
- KwdEn :
Abstract
Coronaviruses (CoVs), a genus containing about 26 known species to date, cause highly prevalent diseases and are often severe or fatal in humans and animals. In 2003, a previously unknown coronavirus was identified to be the etiological agent of a global outbreak of a form of life-threatening pneumonia called severe acute respiratory syndrome (SARS). No efficacious therapy is currently available, and vaccines and drugs are under development to prevent SARS-CoV infection in many countries. The CoV main protease (Mpro), which plays a pivotal role in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, is an attractive target for drug design. This review summarizes the recent advances in biological and structural studies, together with development of inhibitors targeting CoV Mpros. It is expected that inhibitors targeting CoV Mpros could be developed into wide-spectrum antiviral drugs against existing and possible future emerging CoV-associated diseases.
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In 2003, a previously unknown coronavirus was identified to be the etiological agent of a global outbreak of a form of life-threatening pneumonia called severe acute respiratory syndrome (SARS). No efficacious therapy is currently available, and vaccines and drugs are under development to prevent SARS-CoV infection in many countries. The CoV main protease (M<sup>pro</sup>), which plays a pivotal role in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, is an attractive target for drug design. This review summarizes the recent advances in biological and structural studies, together with development of inhibitors targeting CoV M<sup>pro</sup>s. It is expected that inhibitors targeting CoV M<sup>pro</sup>s could be developed into wide-spectrum antiviral drugs against existing and possible future emerging CoV-associated diseases.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Bartlam, Mark" sort="Bartlam, Mark" uniqKey="Bartlam M" first="Mark" last="Bartlam">Mark Bartlam</name><name sortKey="Zihe Rao" sort="Zihe Rao" uniqKey="Zihe Rao" last="Zihe Rao">ZIHE RAO</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Haitao Yang" sort="Haitao Yang" uniqKey="Haitao Yang" last="Haitao Yang">HAITAO YANG</name></noRegion><name sortKey="Haitao Yang" sort="Haitao Yang" uniqKey="Haitao Yang" last="Haitao Yang">HAITAO YANG</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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